Optimization of DNA sequencing

High throughput DNA sequencing technology has greatly increased the speed and reduced the cost of genome sequencing. The process is divided into to two steps: generating a library of short reads and reassembling those reads into the original genome. Eliza O’Reilly, François Baccelli, Gustavo de Veciana, and Haris Vikalo have worked on modeling this process using stochastic geometry and queueing theory in order to optimize the output of correct reads and the probability of successful reassembly (see End-to-End Optimization of High Throughput DNA Sequencing).