| no subj | dose(mouse) | dose(human) | no. wi tumor | prop | binom pi | exact | log likelihood |
| 50 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 50 | 25 | 3.5714286 | 4 | 0.1 | 0.2543 | 0.224524504 | -17.671911 |
| 50 | 50 | 7.1428571 | 20 | 0.4 | 0.5086 | 0.398637755 | -33.650777 |
| 50 | 100 | 14.285714 | 37 | 0.7 | 1.0171 | 0.63836345 | -29.82986 |
| Sum | of log likelihoods = | -81.152547 | |||||
| q = | 0.0711981 | ||||||
| ONE HIT MODEL | |||||||
| Formulas | |||||||
| dose(human) = dose(mouse)/7 | |||||||
| binom pi = q*dose = $D$7*Ci | |||||||
| exact = 1 - expt(q*dose) = 1 - EXP(-$D$7*Ci) | |||||||
| log likelihood = Di*LN(Gi)+(50-Di)*LN(1-Gi) | |||||||
| H6 = Sum(H3:H5) | |||||||
| seed q = .001 | |||||||
| Use Solver to maximize H6 by changing D7 |