no subj | dose(mouse) | dose(human) | no. wi tumor | prop | pi | log likelihood | |
50 | 0 | 0 | 0 | 0 | 0 | ||
50 | 25 | 3.5714 | 4 | 0.08 | 0.1355 | -14.693196 | |
50 | 50 | 7.1429 | 20 | 0.4 | 0.3666 | -33.768935 | |
50 | 100 | 14.286 | 37 | 0.74 | 0.7254 | -28.67979 | |
Sum | -77.141922 | ||||||
q = | 0.1794 | ||||||
TWO HIT MODEL | |||||||
Formulas | |||||||
dose(human) = dose(mouse)/7 | |||||||
Fi= pi=1-(1+q*dose)Exp(-q*dose) = 1-(1+$D$7*Ci)Exp(-$D$7*Ci) | |||||||
log likelihood = Di*LN(Fi)+(50-Di)*LN(1-Fi) | |||||||
G6 = Sum(G3:G5) | |||||||
seed q = .001 | |||||||
Use Solver to maximize G6 by changing D7 |